Connecting Threads: Epigenetics and Metabolism
نویسندگان
چکیده
منابع مشابه
Connecting Threads: Epigenetics and Metabolism
Chromatin-modifying enzymes have long been proposed to be the authors of an epigenetic language, but the origin and meaning of the messages they write in chromatin are still mysterious. Recent studies suggesting that the effects of diet can be passed on epigenetically to offspring add weight to the idea that histones act as metabolic sensors, converting changes in metabolism into stable pattern...
متن کاملMetabolism & epigenetics
Epigenetic regulation of gene activity is of immense importance in maintaining normal and dynamic transcription profiles of practically all cells in our body. In the meantime, cells metabolize nutrients to sustain through different tasks and challenges of life. Both metabolism and gene activity respond to changes in environment. By assessing the relative abundance of certain key compounds centr...
متن کاملBridging epigenetics and metabolism
Recent research suggests that chromatin-modifying enzymes are metabolic sensors regulating gene expression. Epigenetics is linked to metabolomics in response to the cellular microenvironment. Specific metabolites involved in this sensing mechanism include S-adenosylmethionine, acetyl-CoA, alphaketoglutarate and NAD (+) . Although the core metabolic pathways involving glucose have been emphasize...
متن کاملEpigenetics and Cellular Metabolism
Living eukaryotic systems evolve delicate cellular mechanisms for responding to various environmental signals. Among them, epigenetic machinery (DNA methylation, histone modifications, microRNAs, etc.) is the hub in transducing external stimuli into transcriptional response. Emerging evidence reveals the concept that epigenetic signatures are essential for the proper maintenance of cellular met...
متن کاملEpigenetics and metabolism.
The molecular signatures of epigenetic regulation and chromatin architectures are fundamental to genetically determined biological processes. Covalent and post-translational chemical modification of the chromatin template can sensitize the genome to changing environmental conditions to establish diverse functional states. Recent interest and research focus surrounds the direct connections betwe...
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ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.01.001